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Objectives: Monitoring development in infancy results in early detection of developmental delay, and early intervention can prevent sever complications of developmental disorders. The purpose of this study was to determine quality of developmental screening of 3-12 months infants referred to Tehran Health Centers, through comparing with screening by Bayley Infant Neurodevelopmental Screener II (BINS II).

Methods: This was a cross-sectional study. 155 infants of 3-12 months old, recourse to Tehran Health Centers, screened developmentally with BINS II and its results was compared with results of routine clinical examination of Tehran Health Centers.

Results: Kappa agreement between results of BINS II and results of routine developmental screening of Tehran Health Centers’ clinical examination of 3-12-month old infants was poor (0.18).

Discussion: Routine clinical examination in Tehran Health Centers, in compare with applying standard screening tools, cannot screen all infants at risk of developmental delay and ignores many of them which should be considered either for follow up or for receiving early intervention services.