Objectives: Patellofemoral pain syndrome (PFPS) is one of the significant causes of knee pain that results in reduced functional performance.Interventional foot orthotics may lead to improvement in symptoms. In this study, the effects of custom-made foot orthoses with medial heel skive technique on pain and functional performance after four weeks were evaluated. 
Methods: Fourteen subjects with PFPS were given custom-made foot orthoses. The pain and function parameters were evaluated with a visual analog scale (VAS) and Kujala Patellofemoral Score (KPS) before the treatment and at four weeks follow-up. 
Results: Significant improvements in pain was observed in participants with initial pain at four weeks (P<0.001). Also, an increased functional performance was seen in individuals with PFPS at four weeks (P<0.001). 
Discussion: In this study, the custom-made foot orthoses with medial heel skive technique was found to be an effective conservative treatment to reduce the pain and improve the functional performance of patients with PFPS.