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Objectives: The purpose of this study was to investigate the Effectiveness of group Coping Skills training on reducing stress of mothers with mentally retarded children's.

Methods: The research method was quasi experimental with pre-test and post-test design with a control group. Population of the study was all of the mothers of mentally retarded children's that referred to welfare organization centers in Tehran. The sample was 44 mothers of mentally retarded children's that randomly selected from participations that had inclusion criteria. They were placed randomly in case group (22 mothers) and control group (22 mothers). Case group received 12 session’s of coping skills training, while control group didn’t receive any intervention.

Results: The results showed that case group had significantly decreased in stress level after intervention than control group (P<0.001).

Discussion: Results of this study indicated that coping skills training for decreasing stress level of mothers with mentally retarded children's is effective. Based on the results, coping skills training can be considered an effective program for prevention of stress and promoting coping skills in mothers with mentally retarded children's.