en ارتوپدی فنی Orthosis and Prosthesis پژوهشي Original Research Articles <strong>Objectives</strong>: This study aims to determine the association of ambulatory and social performance status of transfemoral prosthetic users with their age, gender, and marital status.<br> <strong>Methods</strong>: A cross-sectional study was conducted on 400 transfemoral prosthesis users. A sample was recruited from both genders aged 10-60 years using the prosthesis for at least one year. They were selected using the non-probability convenience sampling method from the Pakistan Institute of Prosthetic and Orthotic Sciences from July 2019 to December 2019. Lower extremity functional scale and short form-36 health survey questionnaire (SF-36) were used for data collection, followed by statistical analysis.<br> <strong>Results</strong>: Ambulatory status (as measured by the total lower extremity functional scale) revealed significant association (P<0.001) with age. The highest score belonged to the 10-30 years age group. Also, there was a significant association (P=0.003) with marital status with the highest scores for unmarried ones. However, no significant (P=0.705) gender association was noted though scores were higher for the male gender. As regards, the social performance was measured by SF-36. The findings revealed a significant association (P<0.05) of most domains of SF-36 with age groups, with the highest scores for the age group of 10-30 years. Also, a significant association with the gender with higher scores in females was noted in most domains. In contrast, no significant association with marital status was reported in most domains.<br> <strong>Discussion</strong>: Ambulatory status has a significant association with age and marital status with no significant gender association. While social performance has a significant association with gender, most domains had significant associations with age groups. However, no association with marital status was present. Amputation, Functional status, Lower extremity, Mobility, Prosthesis, Quality of Life 369 378 http://irj.uswr.ac.ir/browse.php?a_code=A-10-1335-4&slc_lang=en&sid=1 Shafiq ur Rehman shafiqkhan_dawar@yahoo.com 1 0000-0001-8685-1030 No Isra Institute of Rehabilitation Sciences, Isra University, Islamabad, Pakistan. Aqeel Ahmed Khan aqeelahmed@hotmail.com 2 0000-0002-1567-0918 No Isra Institute of Rehabilitation Sciences, Isra University, Islamabad, Pakistan. Muhammad Kamran drkami772@gmail.com 3 0000-0003-1917-7511 No Isra Institute of Rehabilitation Sciences, Isra University, Islamabad, Pakistan. Ghulam Saqulain ghulam_saqulain@yahoo.com 4 0000-0002-6452-9339 Yes Department of Otorhinolaryngology, Capital Hospital PGMI, Shaheed Zulfiqar Ali Bhutto University, Islamabad, Pakistan. Hilal Ahmed hilal_greensk@yahoo.com 5 0000-0002-9447-0753 No Department of Otorhinolaryngology, Capital Hospital PGMI, Shaheed Zulfiqar Ali Bhutto University, Islamabad, Pakistan.