Iranian Rehabilitation Journal
مجله انگلیسی زبان توانبخشی
Iranian Rehabilitation Journal
Medical Sciences
http://irj.uswr.ac.ir
18
agent2
17353602
17353610
10.29252/nrip.irj
en
jalali
1390
7
1
gregorian
2011
10
1
9
2
online
1
fulltext
en
Identification of Genetic Polymorphism Interactions in Sporadic Alzheimer’s Disease Using Logic Regression
پژوهشي
Original Research Articles
<p style="text-align: justify;"><strong>Objectives:</strong> Genetic polymorphism interactions are among the important factors in affliction with complex diseases like Alzheimer’s disease. The important goal of genetic association studies is to identify a combination of polymorphisms and measure their importance in increasing the risk of occurrence of such diseases. In this study, feature selection approach of logic regression was used to identify the interactions among genetic polymorphisms influential in patients affected with Alzheimer’s disease.</p>
<p style="text-align: justify;"><strong>Methods: </strong>101 Alzheimer’s cases and 109 control subjects from Iranian population were recruited in a case-control study. The evaluation of genes in two groups was performed using molecular technique methods in particular, the PCR-RFLP technique was used to evaluate the intended polymorphisms in APOE, ABCA1, CALHM, CCR2, GSK3β, SAITOHIN, TAU, TNF-α and VDR genes, and then the feature selection approach was used to detect the significance polymorphisms and interactions between them.</p>
<p style="text-align: justify;"><strong>Results:</strong> Based on feature selection approach, the two-way interaction between the polymorphisms of SAITOHIN and APOE genes were significant on occurrence of Alzheimer’s disease.</p>
<p style="text-align: justify;"><strong>Discussion:</strong> Logic regression approach is recommended to detect interaction in the genetic association studies.</p>
Logic regression, Feature selection, Interactions, Genetic polymorphisms, Alzheimer’s disease
45
50
http://irj.uswr.ac.ir/browse.php?a_code=A-10-200-1&slc_lang=en&sid=1
Najimeh
Tarkesh Esfahani
n.tarkesh@gmail.com
1800319475328460010069
1800319475328460010069
No
University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Mehdi
Rahgozar
m.rahgozar@uswr.ac.ir
1800319475328460010070
1800319475328460010070
Yes
University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Akbar
Biglarian
abiglarian@gmail.com
1800319475328460010071
1800319475328460010071
No
University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Hamid Reza
Khorram Khorshid
hrkhkh@yahoo.com
1800319475328460010072
1800319475328460010072
No
Genetic Research Center, University of Social Welfare and Rehabilitation, Tehran, Iran.