Iranian Rehabilitation Journal
Tue, Mar 21, 2023
Volume 21, Issue 1 ((In Press) 2023)
Iranian Rehabilitation Journal 2023, 21(1): 0-0 |
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Oghumu S N, Tella B A, Okafor U C A, Salu O B. Baseline Values of Selected Biochemical Mediators of Pain Implicated in Patients with Non-Specific Chronic Low Back Pain. Iranian Rehabilitation Journal 2023; 21 (1)
URL: http://irj.uswr.ac.ir/article-1-1594-en.html
URL: http://irj.uswr.ac.ir/article-1-1594-en.html
Saturday Nicholas Oghumu * 
1, Bosede Abidemi Tella2 , Udoka Chris Arinze Okafor2 , Olumuyiwa Babalola Salu3
1, Bosede Abidemi Tella2 , Udoka Chris Arinze Okafor2 , Olumuyiwa Babalola Salu3
1- Department of Physiotherapy, School of Postgraduate Studies of the University of Lagos; Department of Physiotherapy, Faculty of Allied Medical Sciences, College of Medical Sciences, University of Calabar, Calabar, Nigeria.
2- Department of Physiotherapy, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Idi-araba, Lagos, Nigeria.
3- Department of Medical Microbiology and Parasitology, Centre for Human & Zoonotic Virology, College of Medicine, University of Lagos, Idi-Araba, Lagos State, Nigeria.
2- Department of Physiotherapy, Faculty of Clinical Sciences, College of Medicine, University of Lagos, Idi-araba, Lagos, Nigeria.
3- Department of Medical Microbiology and Parasitology, Centre for Human & Zoonotic Virology, College of Medicine, University of Lagos, Idi-Araba, Lagos State, Nigeria.
Abstract: (120 Views)
Objectives: Reports of cut-off values of biochemical mediators of pain in patients with low back pain compared to healthy controls are few. This study examined the baseline values of Interleukin (IL) 1A, IL18 Receptor 1 (IL18R1), IL18 Receptor Accessory Protein (IL18RAP), IL6, and Cyclooxygenase-2 (COX2) in a sample of patients with non-specific-chronic-low back pain (NSCLBP) compared to healthy individuals.
Methods: Thirty individuals comprising sixteen patients and fourteen healthy individuals completed this study. Participants’ age, sex, height, weight, body mass index, and percentage of body fat were measured with standard instruments. Also, levels of IL1A, IL18R1, IL18RAP, IL6, and COX2 were assessed with the enzyme-linked immunosorbent assay (ELISA), while patients' pain intensity and level of disability were assessed with visual analogue scale (VAS) and Roland Morris disability questionnaire 24 (RMDQ24), respectively. The collected data were summarized with descriptive statistics and analyzed with inferential statistics at p ≤0.05.
Results: Patients with NSCLBP had higher baseline values of IL1A, IL18R1, IL18RAP, IL6, and COX2 than healthy individuals. Higher statistically significant (p<0.05) IL6 concentration was obtained in patients with NSCLBP than in healthy individuals. Male patients had higher statistically significant (p<0.05) concentrations of IL6 than female patients with NSCLBP. Participants aged 40-60 years had higher mean values of IL1A, IL18R1, IL6, and COX2 than those aged 18-39 years. Pain intensity and level of disability had no significant relationship (p>0.05) with IL1A, IL18R1, IL18RAP, IL6, and COX2 levels.
Discussion: Patients with NSCLBP have a higher concentration of IL6 than healthy individuals, and being male with NSCLBP is a risk factor for higher expression of IL6. Factors of age and sex are notable determinants of cytokine expression.
Methods: Thirty individuals comprising sixteen patients and fourteen healthy individuals completed this study. Participants’ age, sex, height, weight, body mass index, and percentage of body fat were measured with standard instruments. Also, levels of IL1A, IL18R1, IL18RAP, IL6, and COX2 were assessed with the enzyme-linked immunosorbent assay (ELISA), while patients' pain intensity and level of disability were assessed with visual analogue scale (VAS) and Roland Morris disability questionnaire 24 (RMDQ24), respectively. The collected data were summarized with descriptive statistics and analyzed with inferential statistics at p ≤0.05.
Results: Patients with NSCLBP had higher baseline values of IL1A, IL18R1, IL18RAP, IL6, and COX2 than healthy individuals. Higher statistically significant (p<0.05) IL6 concentration was obtained in patients with NSCLBP than in healthy individuals. Male patients had higher statistically significant (p<0.05) concentrations of IL6 than female patients with NSCLBP. Participants aged 40-60 years had higher mean values of IL1A, IL18R1, IL6, and COX2 than those aged 18-39 years. Pain intensity and level of disability had no significant relationship (p>0.05) with IL1A, IL18R1, IL18RAP, IL6, and COX2 levels.
Discussion: Patients with NSCLBP have a higher concentration of IL6 than healthy individuals, and being male with NSCLBP is a risk factor for higher expression of IL6. Factors of age and sex are notable determinants of cytokine expression.
Keywords: Baseline values, Cut-off values, Biochemical mediators, Cytokine levels, Non-specific chronic low back pain
Article type: Original Research Articles |
Subject:
chronic pain
Received: 2022/02/3 | Accepted: 2022/12/14 | Published: 2023/03/19
Received: 2022/02/3 | Accepted: 2022/12/14 | Published: 2023/03/19
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