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• Strengthening resilience skills can reduce the stress on mothers of children with Down syndrome (DS). 
• After the training program, there was a significant difference between the mean stress scores of the two groups. 
• Plain language summary: Strengthening the resilience skills of mothers of children with DS can reduce the stress of these mothers, increase their quality of life, and ultimately increase the quality of life of other family members

Plain Language Summary 
Down's syndrome (DS), also known as trisomy 21, is a genetic disorder. It is usually associated with developmental delays, mild to moderate intellectual disability, and characteristic physical features. There is no cure for this disease. Education and proper care have been shown to provide good quality of life. Families who care for a child with DS at home face a variety of psychological, social, and economic problems. Parents of these children experience more stress compared to normal children's parents. Parenting stress has deleterious effects on parents, children, and overall family functioning. Parents of children with intellectual disability, including DS, showed higher levels of parenting stress than parents of normal children. In this study, we aim to investigate the effect of resilience skills on reducing the stress of the mothers of these children. Resilience is the process and outcome of successfully adapting to difficult or challenging life experiences, and adjustment to external and internal demands. Strengthening the resilience skills of mothers of children with DS can reduce the stress of these mothers, increase their quality of life and ultimately increase the quality of life of other family members. Combing social support with resilience training may be more effective in mitigating carer-stress among parents of children with DS.