en ارتوپدی فنی Orthosis and Prosthesis پژوهشي Original Research Articles <strong>Objectives</strong>: The main objective of this study was to culturally adapt the original English version of the Physical Activity Scale For Individuals with Physical Disabilities (PASIPD) for the Persian-speaking patients with Lower-Limb Amputations (LLAs) and to evaluate its reliability and construct validity.<br> <strong>Methods</strong>: This research was a multicenter cross-sectional and repeated measure study. The cultural adaptation process was conducted according to an accepted international guideline. A total of 197 Persian-speaking individuals with LLA were recruited to investigate the reliability and validity of the PASIPD. Reliability analyses were assessed by Cronbach &alpha; and the Pearson product-moment correlation coefficient. The Association between the PASIPD scores and the prosthetic limb user survey of mobility scores was examined to evaluate the convergent validity of the PASIPD. Known-groups validity was assessed based on sex, amputation causes, and amputation levels.<br> <strong>Results</strong>: The PASIPD had an acceptable internal uniformity (the Cronbach &alpha; of 0.68) and test-retest reproducibility (r=0.70). There was a small correlation between the PASIPD and prosthetic limb user mobility survey (r=0.26; P<0.001). Some items of PASIPD could discriminate individuals with different causes of amputation and sex. Factor analysis extracted four main factors that explained 65.4% of the variance.<br> <strong>Discussion</strong>: The Persian version of the PASIPD has acceptable reliability and validity for assessing the physical activity of persons with LLAs. Reliability and Validity, Physical activity, Amputation, Questionnaire 61 72 http://irj.uswr.ac.ir/browse.php?a_code=A-10-1505-1&slc_lang=en&sid=1 Mohaddeseh Asgari mohaddeseh.asgari93@gmail.com 0000-0002-8578-9092 No Department of Prosthetics and Orthotics, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran. Taher Babaee taher.to3@gmail.com 0000-0002-1487-2374 Yes Department of Prosthetics and Orthotics, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran. Maryam Jalali marjalali@gmail.com 0000-0002-5442-0487 No Department of Prosthetics and Orthotics, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran. Hassan Saeedi hassan_saeedi2@yahoo.co.uk 0000-0001-7066-5081 No Department of Prosthetics and Orthotics, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran.