en پژوهشي Original Research Articles <p style="text-align: justify;"><strong>Objectives:</strong> Genetic polymorphism interactions are among the important factors in affliction with complex diseases like Alzheimer&rsquo;s disease. The important goal of genetic association studies is to identify a combination of polymorphisms and measure their importance in increasing the risk of occurrence of such diseases. In this study, feature selection approach of logic regression was used to identify the interactions among genetic polymorphisms influential in patients affected with Alzheimer&rsquo;s disease.</p> <p style="text-align: justify;"><strong>Methods: </strong>101 Alzheimer&rsquo;s cases and 109 control subjects from Iranian population were recruited in a case-control study. The evaluation of genes in two groups was performed using molecular technique methods in particular, the PCR-RFLP technique was used to evaluate the intended polymorphisms in APOE, ABCA1, CALHM, CCR2, GSK3&beta;, SAITOHIN, TAU, TNF-&alpha; and VDR genes, and then the feature selection approach was used to detect the significance polymorphisms and interactions between them.</p> <p style="text-align: justify;"><strong>Results:</strong> Based on feature selection approach, the two-way interaction between the polymorphisms of SAITOHIN and APOE genes were significant on occurrence of Alzheimer&rsquo;s disease.</p> <p style="text-align: justify;"><strong>Discussion:</strong> Logic regression approach is recommended to detect interaction in the genetic association studies.</p> Logic regression, Feature selection, Interactions, Genetic polymorphisms, Alzheimer’s disease 45 50 http://irj.uswr.ac.ir/browse.php?a_code=A-10-200-1&slc_lang=en&sid=1 Najimeh Tarkesh Esfahani n.tarkesh@gmail.com No University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Mehdi Rahgozar m.rahgozar@uswr.ac.ir Yes University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Akbar Biglarian abiglarian@gmail.com No University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Hamid Reza Khorram Khorshid hrkhkh@yahoo.com No Genetic Research Center, University of Social Welfare and Rehabilitation, Tehran, Iran.