en مدیریت توانبخشی Rehabilitation Management مروري Reviews <div style="text-align: justify;"><strong>Objectives</strong>: This study evaluates the efficacy and safety of biological therapies in treating knee osteoarthritis (OA), focusing on platelet-rich plasma (PRP), hyaluronic acid (HA), and stem cell therapies.<br> <strong>Methods</strong>: A comprehensive review of studies from the past decade was conducted, utilizing databases, such as PubMed, CENTRAL, Web of Science, and Embase. Keywords included &ldquo;knee OA,&rdquo; &ldquo;PRP,&rdquo; &ldquo;hyaluronic acid,&rdquo; and &ldquo;stem cell therapies.&rdquo; A total of 67 relevant studies, including reviews, original research, and meta-analyses, were analyzed.<br> <strong>Results</strong>: Biological therapies offer significant advancements in OA management. PRP demonstrates anti-inflammatory properties and appears to enhance cartilage repair, particularly effective in early to intermediate stages. HA improves joint lubrication and mobility, suitable for mild to moderate OA. Stem cell therapies show promising results in cartilage regeneration and inflammatory modulation, particularly in advanced cases. However, challenges such as standardization, cost, and accessibility limit widespread adoption.<br> <strong>Discussion</strong>: PRP, HA, and stem cell therapies provide innovative approaches to knee OA treatment, addressing pain, inflammation, and cartilage regeneration. Further research is essential to optimize protocols and improve accessibility, ensuring personalized and effective treatments for diverse patient populations.</div> Osteoarthritis, Knee, Platelet-rich plasma (PRP), Hyaluronic acid (HA), Mesenchymal stem cells (MSCs), Regenerative medicine 11 26 http://irj.uswr.ac.ir/browse.php?a_code=A-10-2491-1&slc_lang=en&sid=1 Marcin Tomaszewski m.tomaszewski@ptmk.org 0009-0005-1011-6669 No Department of Clinical Research and Development, LUXMED Group, Warsaw, Poland. Michal Pruc m.pruc@ptmk.org 0000-0002-2140-9732 No Institute of Medical Science, The John Paul II Catholic University of Lublin, Lublin, Poland. Piotr Fudalej piofudalej@gmail.com 0009-0003-5361-9384 No ORTHOS Multi-Specialty Hospital Komorowice, LUXMED Group, Komorowice, Poland. Francesco Chirico medlavchirico@gmail.com 0000-0002-8737-4368 No Department of Security and Bioethics, Section of Occupational Health, Università Cattolica del Sacro Cuore, Rome, Italy. Mahdi Al-Jeabory mmahdi@interia.pl 0000-0003-4412-6409 No Department of Clinical Orthopedic, Silesian Center for Rheumatology in Ustron, Ustron, Poland. Khabbache Hicham Hichamcogn@gmail.com 0000-0001-9587-2829 No Department of Psychology, Faculty of Arts and Human Sciences Fès-Saïss, Sidi Mohamed Ben Abdellah University, Fez, Morocco. Majid Ansari majid.ansari@gmail.com 0000-0001-9506-774X No Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran. Morteza Faghih Jouibari mortezafaghihj@yahoo.com 0000-0001-9171-0830 No Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran. Lukasz Szarpak lukasz.szarpak@gmail.com 0000-0002-0973-5455 Yes Institute of Medical Science, The John Paul II Catholic University of Lublin, Lublin, Poland.