en پژوهشي Original Research Articles <p style="text-align: justify;"><strong>Objectives: </strong>The aim of the study was to determine the effect of a selected exercise training on reducing symptoms of dementia caused by Alzheimer&#39;s disease in people with Down syndrome.</p> <p style="text-align: justify;"><strong>Methods:</strong> 27 men with Down syndrome were randomized to intervention (n=13) and control (n=13) groups. All persons in experimental group followed 12 weeks selected exercise training, three times a week. Prior to the start of the study, and after three-month training, each member in both groups was assessed according to the DSQIID questionnaire filled by caregivers of these peoples. Data were analysed by independent t-test.</p> <p style="text-align: justify;"><strong>Results:</strong> The results indicated that the first questionnaire subscales that assess memory disorders and confusion in the experimental group between pre and post test showed a significant decrease (P=0.028). Also in third part of questionnaire that asked about the individual skills, social withdrawal, physical symptoms and speech abnormalities, the variable scores in post-test of experimental group were significantly lower than pre-test scores (P=0.047).</p> <p style="text-align: justify;"><strong>Discussion:</strong> These result showed that the combination of selected exercises training could cause a significant reduction in the incidence of initial dementia symptoms and can be an important step to prevent of the dementia in these people.</p> Selected exercise training, Dementia, Down syndrome 35 45 http://irj.uswr.ac.ir/browse.php?a_code=A-10-288-1&slc_lang=en&sid=1 Zahra Sarlak zahrasarlak59@yahoo.com No Department of Physical Education, Khodabandeh Branch, Islamic Azad University, Khodabandeh, Iran. Asghar Dadkhah asgaredu@gmail.com Yes Iranian Research Center on Ageing, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Ali Kashi ssrc.kashi@yahoo.com No Sport Science Research Institute of Ministry of Science, Research and Technology of Iran, Tehran, Iran. Mahmood Sheikh prosheikh@yahoo.com No Department of Sport Physiology, Faculty of Physical Education and Sports Sciences, University of Tehran, Tehran, Iran.