en پژوهشي Original Research Articles <div style="text-align: justify;"><span style="font-size:12px;"><font class="Apple-style-span" face="arial, helvetica, sans-serif"><strong>Objectives:</strong> Multiple Sclerosis is the most prevalent central nervous system diseases thatdue to being chronic, frequent recurrence, uncertainty about its progress, and disability, can lead to various distresses as well as demoralization . Rehabilitation method based on Cognitive-Existential therapy is an integratedapproach which can help to decrease demoralization syndrome in these patients. This study aimed to exploring effectiveness of rehabilitation method based on Cognitive-Existential approach on decreasing demoralization syndrome in patients with MS. </font></span></div> <div style="text-align: justify;"><span style="font-size:12px;"><font class="Apple-style-span" face="arial, helvetica, sans-serif"><strong>Methods:</strong> Single subject design is used in this study. Among women who had referred to Tehran MS Association, 3 women (aged between 20-40) were selected through purposeful sampling and separately participated in 10 sessions (90 minutes). Participants were assessed during 7 phases of intervention (2 baselines, 3 measurement during intervention, 2 follow-up) through Demoralization Syndrome Scale (2004) and Cognitive Distortion scale (2010). Data were analyzed by calculating process variation index and visual analysis.</font></span></div> <div style="text-align: justify;"><span style="font-size:12px;"><strong>Results:</strong> Comparing patients with MS scores on the diagram during 7 time measurement and calculating recovery percentage, represent decreasing in demoralization syndrome score scale.</span></div> <div style="text-align: justify;"><span style="font-size:12px;"><font class="Apple-style-span" face="arial, helvetica, sans-serif"><strong>Discussions:</strong> Findings showed that rehabilitation method based on Cognitive Existential approach can decrease demoralization syndrome in patients with MS. </font></span></div> Cognitive distortion, Cognitive–existential therapy, Multiple sclerosis, Demoralization syndrome. 28 33 http://irj.uswr.ac.ir/browse.php?a_code=A-10-465-1&slc_lang=en&sid=1 Nasim Pakniya n.pakniya87@gmail.com No University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Bahman Bahmani bbahmani43@yahoo.com Yes University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Asghar Dadkhah drdadkhah@yahoo.com No University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Mojtaba Azimian mazimian@yahoo.com No University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Maedeh Naghiyaee maedehnaghiyaee@yahoo.com No University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Raheleh MasudiSani rahelemasoudi@yahoo.com No University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.