en روانشناسی Psychology پژوهشي Original Research Articles <div style="text-align: justify;"><strong>Objectives</strong>: The modulation of the dorsolateral prefrontal cortex (DLPFC) activity enhanced the prospects of substance use disorders rehabilitation, using non-invasive brain stimulation, such as transcranial Direct Current Stimulation (tDCS).<br> <strong>Methods</strong>: We carried out a randomized sham-controlled clinical trial to assess the effect of repeated tDCS at DLPFC on drug craving in 30 abstinent male methamphetamine users. The participants underwent 5 sessions of 20 minutes bilateral real or sham 2 mA tDCS (anode right/ cathode left) of DLPFC. The Desire for Drug Questionnaire (DDQ) was used for assessing instant craving. The cue-induced craving was rated on a Visual Analog Scale (VAS) after the verbal induction of craving.<br> <strong>Results</strong>: The findings of this study indicated that cue-induced craving reduced significantly in tDCS related to sham (P<0.05), but tDCS did not significantly alter instant craving.<br> <strong>Discussion</strong>: The results indicated that repeated bilateral tDCS over DLPFC was not effective in reducing self-report instant craving, but reduced self-reported craving in the craving induction condition.</div> Transcranial Direct Current Stimulation, Methamphetamine craving, Dorsolateral prefrontal cortex 385 394 http://irj.uswr.ac.ir/browse.php?a_code=A-10-699-1&slc_lang=en&sid=1 Mahsa Rohani Anaraki mahsa.rohani90@gmail.com 0000-0001-5304-9383 No Department of Clinical Psychology, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Behrouz Dolatshahi dolatshahee@yahoo.com 0000-0003-2230-9562 Yes Department of Clinical Psychology, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Masoud Nosratabadi masoudnosratabadi@gmail.com 0000-0001-9080-9070 No Department of Clinical Psychology, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Mohsen Nouri Yalghouzaghaji Omid.nouri9@gmail.com 0000-0003-2294-8663 No Department of Clinical Psychology, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Sajede Rezaei Mashhadi sajederezaee@gmail.com 0000-0002-9340-9635 No Department of Clinical Psychology, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.