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Oronasal region, as an important organ of taste and smell, being respected for its impact on the resonace, which is crucial for any normal speech production. Different congenital, acquired and/or developmentalpdefect, may not only have impacts on the quality of respiration, phonation, resonance, also on the process of a normal speech. This article will enable readers to have more focus in such important neuroanatomical speech zones disorders and their respective proper rehabilitation methods in different derangements. Among all other defects, oronasal malfunctionings would definitely has an influence on the oronasal sound resonance and furtherly render impairments on a normal speech production. Rehabilitative approach by speech and language pathologist is highly recommended to alleviate most of oronasal speech disorders.