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Objectives: To compare the effectiveness of two treatment methods of ‘combination pharmacological treatment and treadmill training’ and ‘pharmacological treatment’ on management of multiple sclerosis (MS) female patients.

Methods: In this quasi experimental and interventional study a sample of 20 MS patients (mean age: 36.75 years) with Expanded Disability Status Scale scores (EDSS) 1.0 to 4.0 were randomly assigned to a ‘pharmacologic treatment’ (Ph) group and a combination group of ‘pharmacologic treatment& treadmill training’ (PhTT). All these individuals used the drugs of choice ‘Rebif’ and ‘Avonex’. The intervention consisted of 8-weeks (24 sessions) of treadmill training (30 minutes each), at 40-75% of age-predicted maximum heart rate for the PhTT group. The Ph group followed their own routine treatment program. Balance, speed and endurance of walking, quality of life and fatigue were measured by Berg Balance Score, 10 meter timed walk test, 2 minute walk test, and Fatigue Severity Scale (FFS). Data were analyzed by paired t test and one way ANOVA.

Results: Comparison of results indicated that pre and post intervention led to significant improvements in the balance score (P=0.001), 10m walk time (P=0.001), walking endurance (P=0.007), and FFS (P=0.04) in the PhTT group. In contrast, no significant changes were observed in the Ph group’s balance score, 10m timed walk and fatigue, while there was a significant decrease in the 2min walking distance (P=0.015) in this group.

Discussion: These results suggest that treadmill training in combination with pharmacological treatment improve balance and walking capacity and level of fatigue in women with mild to moderate MS.