Objectives: Deaf and hard-of-hearing (DHH) people experience a variety of psychological distress. The quality of life (QoL), health, stress, anxiety, and depression in DHH adolescents can affect their psychological well-being. This study aimed to predict psychological well-being based on psychosocial factors in DHH adolescents. 
Methods: A total of 120 DHH adolescents participated in the current cross-sectional study. Adolescents were chosen through a convenient sampling method from secondary deaf schools in Isfahan, Iran in 2020. These adolescents were assessed with the KIDSCREEN-27 health-related QoL questionnaire, youth QoL instrument-deaf and hard of hearing (YQOL-DHH), and depression, anxiety, stress scales (DASS-21). 
Results: Perceived stigma, stress, anxiety, and depression had a significant and negative relationship with psychological well-being, while self-advocacy/acceptance, participation, physical well-being, social support, school environment, and parent relations had a significant and positive relationship with the psychological well-being of DHH adolescents. These variables predicted 89% of the psychological well-being of these adolescents. 
Discussion: Findings suggest that the QoL, health, stress, anxiety, and depression were significant predictors of the well-being of DHH adolescents.