The main goal of this report was to share with clinicians an atypical presentation of pulmonary thromboembolism (PTE) in a young male`s post-appendectomy, whom he had no significant predisposing factors for such disease. The case also introduced for re-examining the challenges of PTE clinical manifestations which may mimic other differential diagnosis. PTE is an abrupt blockage of the pulmonary artery by a thrombus. Such thrombus is generated by a blood clot which has been formed, separated and migrated from the leg and/or pelvic veins toward the lung.The lung tissue`s circulation is impaired which later episode results hypoxia and infarction. These events initiate a set of PTE clinical manifestations.