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Objectives: Nurses of mentally disabled adults’ centers are encountered with high pressures and stresses and the objective of this study is the investigation of the relationship between the mental pressure of the nurses of mentally disabled adults’ centers and their job burnout.

Methods: This study was done on 180 nurses of different shifts of Nurses of mentally disabled adults’ centers of Mashhad in different shifts and the data were analyzed by job stress questionnaires based on likert scale and job burnout in Guttman scale and by Pearson correlation coefficient and SPSS software.

Results: The results showed that in all nurses of mentally disabled adults’ centers, there was a significant relationship between the stress of job roles and burnout and the stress of personal pressures and burnout and the amount of using the resources to cope with their job stress and burnout.

Discussion: Based on the results of this study we can conclude that as nursing job in mentally disabled adults’ centers is of high mental pressure jobs, the stress of this job causes different burnouts including job burnout.