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Rohani Anaraki M, Dolatshahi B, Nosratabadi M, Nouri Yalghouzaghaji M, Rezaei Mashhadi S. Repeated Transcranial Direct Current Stimulation (tDCS) on Methamphetamine Craving: A Randomized, Sham-controlled Study. Iranian Rehabilitation Journal 2019; 17 (4) :385-394
URL: http://irj.uswr.ac.ir/article-1-841-en.html

Objectives: The modulation of the dorsolateral prefrontal cortex (DLPFC) activity enhanced the prospects of substance use disorders rehabilitation, using non-invasive brain stimulation, such as transcranial Direct Current Stimulation (tDCS).
Methods: We carried out a randomized sham-controlled clinical trial to assess the effect of repeated tDCS at DLPFC on drug craving in 30 abstinent male methamphetamine users. The participants underwent 5 sessions of 20 minutes bilateral real or sham 2 mA tDCS (anode right/ cathode left) of DLPFC. The Desire for Drug Questionnaire (DDQ) was used for assessing instant craving. The cue-induced craving was rated on a Visual Analog Scale (VAS) after the verbal induction of craving.
Results: The findings of this study indicated that cue-induced craving reduced significantly in tDCS related to sham (P<0.05), but tDCS did not significantly alter instant craving.
Discussion: The results indicated that repeated bilateral tDCS over DLPFC was not effective in reducing self-report instant craving, but reduced self-reported craving in the craving induction condition.