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Wed, May 27, 2026
Volume 24, Issue 1 (March-In press 2026)
Iranian Rehabilitation Journal 2026, 24(1): 11-26 |
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Tomaszewski M, Pruc M, Fudalej P, Chirico F, Al-Jeabory M, Hicham K, et al . Biological Therapies in Treating Knee Osteoarthritis: A Narrative Review. Iranian Rehabilitation Journal 2026; 24 (1) :11-26
URL: http://irj.uswr.ac.ir/article-1-2444-en.html
URL: http://irj.uswr.ac.ir/article-1-2444-en.html
Marcin Tomaszewski1 
, Michal Pruc1 , Piotr Fudalej2 , Francesco Chirico3 , Mahdi Al-Jeabory4 , Khabbache Hicham5 , Majid Ansari6 , Morteza Faghih Jouibari7 , Lukasz Szarpak *8
, Michal Pruc1 , Piotr Fudalej2 , Francesco Chirico3 , Mahdi Al-Jeabory4 , Khabbache Hicham5 , Majid Ansari6 , Morteza Faghih Jouibari7 , Lukasz Szarpak *8
1- Department of Clinical Research and Development, LUXMED Group, Warsaw, Poland.
2- Department of Clinical Research and Development, LUXMED Group, Warsaw, Poland. & ORTHOS Multi-Specialty Hospital Komorowice, LUXMED Group, Komorowice, Poland.
3- Post-Graduate School of Occupational Health, Università Cattolica del Sacro Cuore, Rome, Italy
4- Department of Clinical Research and Development, LUXMED Group, Warsaw, Poland. & Trauma and Orthopedic Surgery, Silesian Center for Rheumatology in Ustron, Ustron, Poland & Clinical Department of Orthopedic, Trauma, Oncological and Reconstructive Surgery
5- Department of Psychology, Faculty of Arts and Human Sciences Fès-Saïss, Sidi Mohamed Ben Abdellah University, Fez, Morocco. & Director of Lifelong Learning Observatory (UNESCO/ USMBA), Fez, Morocco.
6- Department of neurosurgery.Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
7- Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
8- Department of Clinical Research and Development, LUXMED Group, Warsaw, Poland. & Institute of Medical Science, Collegium Medicum, The John Paul II Catholic University of Lublin, Lublin, Poland. & Henry JN Taub Department of Emergency Medicine, Baylor College of Medicine, Houston, TX, USA.
2- Department of Clinical Research and Development, LUXMED Group, Warsaw, Poland. & ORTHOS Multi-Specialty Hospital Komorowice, LUXMED Group, Komorowice, Poland.
3- Post-Graduate School of Occupational Health, Università Cattolica del Sacro Cuore, Rome, Italy
4- Department of Clinical Research and Development, LUXMED Group, Warsaw, Poland. & Trauma and Orthopedic Surgery, Silesian Center for Rheumatology in Ustron, Ustron, Poland & Clinical Department of Orthopedic, Trauma, Oncological and Reconstructive Surgery
5- Department of Psychology, Faculty of Arts and Human Sciences Fès-Saïss, Sidi Mohamed Ben Abdellah University, Fez, Morocco. & Director of Lifelong Learning Observatory (UNESCO/ USMBA), Fez, Morocco.
6- Department of neurosurgery.Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
7- Sports Medicine Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
8- Department of Clinical Research and Development, LUXMED Group, Warsaw, Poland. & Institute of Medical Science, Collegium Medicum, The John Paul II Catholic University of Lublin, Lublin, Poland. & Henry JN Taub Department of Emergency Medicine, Baylor College of Medicine, Houston, TX, USA.
Abstract: (2019 Views)
Objectives: This study evaluates the efficacy and safety of biological therapies in treating knee osteoarthritis (OA), focusing on platelet-rich plasma (PRP), hyaluronic acid (HA), and stem cell therapies.
Methods: A comprehensive review of studies from the past decade was conducted, utilizing databases, such as PubMed, CENTRAL, Web of Science, and Embase. Keywords included “knee OA,” “PRP,” “hyaluronic acid,” and “stem cell therapies.” A total of 67 relevant studies, including reviews, original research, and meta-analyses, were analyzed.
Results: Biological therapies offer significant advancements in OA management. PRP demonstrates anti-inflammatory properties and appears to enhance cartilage repair, particularly effective in early to intermediate stages. HA improves joint lubrication and mobility, suitable for mild to moderate OA. Stem cell therapies show promising results in cartilage regeneration and inflammatory modulation, particularly in advanced cases. However, challenges such as standardization, cost, and accessibility limit widespread adoption.
Discussion: PRP, HA, and stem cell therapies provide innovative approaches to knee OA treatment, addressing pain, inflammation, and cartilage regeneration. Further research is essential to optimize protocols and improve accessibility, ensuring personalized and effective treatments for diverse patient populations.
Methods: A comprehensive review of studies from the past decade was conducted, utilizing databases, such as PubMed, CENTRAL, Web of Science, and Embase. Keywords included “knee OA,” “PRP,” “hyaluronic acid,” and “stem cell therapies.” A total of 67 relevant studies, including reviews, original research, and meta-analyses, were analyzed.
Results: Biological therapies offer significant advancements in OA management. PRP demonstrates anti-inflammatory properties and appears to enhance cartilage repair, particularly effective in early to intermediate stages. HA improves joint lubrication and mobility, suitable for mild to moderate OA. Stem cell therapies show promising results in cartilage regeneration and inflammatory modulation, particularly in advanced cases. However, challenges such as standardization, cost, and accessibility limit widespread adoption.
Discussion: PRP, HA, and stem cell therapies provide innovative approaches to knee OA treatment, addressing pain, inflammation, and cartilage regeneration. Further research is essential to optimize protocols and improve accessibility, ensuring personalized and effective treatments for diverse patient populations.
Keywords: Osteoarthritis, Knee, Platelet-rich plasma (PRP), Hyaluronic acid (HA), Mesenchymal stem cells (MSCs), Regenerative medicine
Article type: Reviews |
Subject:
Rehabilitation Management
Received: 2025/01/6 | Accepted: 2025/07/29 | Published: 2026/03/1
Received: 2025/01/6 | Accepted: 2025/07/29 | Published: 2026/03/1
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